Elution and antibacterial activity of meropenem from implanted acrylic bone cement.
نویسندگان
چکیده
References 1 Nordmann P, Cuzon G, Naas T. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect Dis 2009; 9: 228–36. 2 Wolter DJ, Kurpiel PM, Woodford N et al. Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. Antimicrob Agents Chemother 2009; 53: 557–62. 3 Endimiani A, Patel G, Hujer KM et al. In vitro activity of fosfomycin against blaKPC-containing Klebsiella pneumoniae isolates, including those nonsusceptible to tigecycline and/or colistin. Antimicrob Agents Chemother 2010; 54: 526–9. 4 Endimiani A, Hujer AM, Perez F et al. Characterization of blaKPCcontaining Klebsiella pneumoniae isolates detected in different institutions in the Eastern USA. J Antimicrob Chemother 2009; 63: 427–37. 5 Anderson KF, Lonsway DR, Rasheed JK et al. Evaluation of methods to identify the Klebsiella pneumoniae carbapenemase in Enterobacteriaceae. J Clin Microbiol 2007; 45: 2723–5. 6 Pasteran F, Mendez T, Rapoport M et al. Controlling the false positive results of the Hodge and Masuda assays for class A carbapenemase detection in species of Enterobacteriaceae. J Clin Microbiol 2010; 47: 1631–9. 7 Ecker DJ, Sampath R, Massire C et al. Ibis T5000: a universal biosensor approach for microbiology. Nat Rev Microbiol 2008; 6: 553–8. 8 Hujer KM, Hujer AM, Endimiani A et al. Rapid determination of quinolone resistance in Acinetobacter spp. J Clin Microbiol 2009; 47: 1436–42. 9 Endimiani A, Depasquale JM, Forero S et al. Emergence of blaKPCcontaining Klebsiella pneumoniae in a long-term acute care hospital: a new challenge to our healthcare system. J Antimicrob Chemother 2009; 64: 1102–10. 10 Paterson DL, Hujer KM, Hujer AM et al. Extended-spectrumb-lactamases in Klebsiella pneumoniae bloodstream isolates from seven countries: dominance and widespread prevalence of SHVand CTX-M-type b-lactamases. Antimicrob Agents Chemother 2003; 47: 3554–60.
منابع مشابه
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عنوان ژورنال:
- The Journal of antimicrobial chemotherapy
دوره 65 8 شماره
صفحات -
تاریخ انتشار 2010